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Avandamet along with diet and exercise helps improve blood sugar control. It is a combination of two drugs - rosiglitazone maleate and metformin HCl. AVANDAMET (rosiglitazone maleate and metformin hydrochloride) AVANDAMET (rosiglitazone maleate and metformin HCl) tablets contain 2 oral antihyperglycemic drugs used in the management of type 2 diabetes: Avandamet⢠(rosiglitazone maleate and metformin hydrochloride) Tablets (rosiglitazone maleate and metformin hydrochloride) Tablets Avandamet along with diet and exercise helps improve blood sugar control. 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